Medicines · Natural / Botanical
API Melafix
- Active Ingredient
- Melaleuca alternifolia extract (1.0% tea tree oil)
- Medicine Type
- Natural / Botanical

Observe and distinguish
Identification and context
Identity and formulation
API MELAFIX contains 1% cajuput oil according to DailyMed; it is not tea-tree/Melaleuca alternifolia oil. The US label lists uses for wounds and external signs, but DailyMed classifies it as an unapproved drug: label claims are not equivalent to demonstrated clinical efficacy.
Supported indications
The label proposes use for abrasions, wounds and some external signs. A study of fish pathogens found no significant in-vitro antibacterial activity under the tested conditions: it does not replace diagnosis, culture or veterinary treatment for progressive or systemic infection.
Diagnostic prerequisites
Confirm host, diagnosis, net volume, water quality and exact formulation before use. Do not transfer directions between products.
Verify before intervening
Confirmation and decisions
Label directions
For the exact US DailyMed formulation only: 5 mL per 38 L once daily for 7 days, followed by a 25% water change; for new fish, once daily for 3 days. Verify the current local label.
Preparation and monitoring
United States: DailyMed lists cajuput oil 1% and status “unapproved drug other”; the label has not been approved by FDA. Claims, dosage and status are formulation- and jurisdiction-specific.
Species and system compatibility
Not for fish intended for human consumption. Do not generalize tolerance observed in a few species to all fish, invertebrates, corals or life stages; maintain aeration, stop if distress occurs, and seek veterinary care if signs progress.
Interactions and contraindications
Not for fish intended for human consumption. Do not generalize tolerance observed in a few species to all fish, invertebrates, corals or life stages; maintain aeration, stop if distress occurs, and seek veterinary care if signs progress.
Proportionate actions
Management and monitoring
Adverse effects and failure
Not for fish intended for human consumption. Do not generalize tolerance observed in a few species to all fish, invertebrates, corals or life stages; maintain aeration, stop if distress occurs, and seek veterinary care if signs progress.
Operator safety
United States: DailyMed lists cajuput oil 1% and status “unapproved drug other”; the label has not been approved by FDA. Claims, dosage and status are formulation- and jurisdiction-specific.
Regulatory status
Check authorisation, prescription status and conditions of use in the user’s jurisdiction; ornamental and food-producing animals are not interchangeable.
Evidence limitations
Manufacturer directions document only the stated formulation. Efficacy, safety and dosage do not automatically extend to the active substance or other products.
Active ingredient identity
Composition and chemical data
Botanical extract of Melaleuca. Its primary active component is terpinen-4-ol, which provides natural antibacterial properties.
Transparency
Information and documentation
Information
- Active Ingredient
- Melaleuca alternifolia extract (1.0% tea tree oil)
- Medicine Type
- Natural / Botanical
Documentation
- Product Page
DailyMed — API MELAFIX (cajuput oil 1%)
REGULATORYHIGHApplies only to the stated jurisdiction, product, formulation and revision date.
- Product Page
Journal of Exotic Pet Medicine — Safety and efficacy evaluation of Melafix
PRIMARY RESEARCHMEDIUMStudy findings apply to the reported taxa, methods and conditions; transfer to other aquaria is an inference.